The pattern of nucleotide difference at individual codons among mouse, rat, and human.

نویسندگان

  • Robert Friedman
  • Austin L Hughes
چکیده

The patterns of nucleotide difference were compared at 3,473,111 codons from 9,390 aligned orthologous genes of mouse (Mus musculus), rat (Rattus norvegicus), and human (Homo sapiens). The results showed evidence of a higher frequency of both synonymous and nonsynonymous differences from human in the rat than in the mouse. However, contrary to a previous report, there was no evidence of a greater frequency of codons with multiple nonsynonymous substitutions between the two rodent species than expected under random substitution.

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عنوان ژورنال:
  • Molecular biology and evolution

دوره 22 5  شماره 

صفحات  -

تاریخ انتشار 2005